The roleplay begins with a scientist preparing a patient for a dangerous procedure. The patient is suffering from a terminal illness and volunteers for an experimental treatment. The scientist reassures the patient, then leaves the room as the procedure begins. The setting shifts to Raccoon City, which is overrun by zombies. The scientist, having been abandoned by Umbrella Corporation, struggles to survive in the ravaged city. The roleplay culminates in an encounter with Nemesis, who confronts the scientist in a ruined grocery store.